| LB Mohamoud Diabate - Hip, IR. Injured Reserve. Expected Return - Week 6 |
WR Johnny Wilson - Concussion, Full Practice on Wednesday. Questionable for Week 6 vs. Cleveland |
| G Zak Zinter - Knee, Limited Practice on Wednesday. Questionable for Week 6 at Philadelphia |
LB Nakobe Dean - Ankle, Limited Practice on Wednesday. Questionable for Week 6 vs. Cleveland |
| OT Jedrick Wills - Knee, Questionable for Week 6 at Philadelphia |
WR DeVonta Smith - Concussion, Full Practice on Wednesday. Questionable for Week 6 vs. Cleveland |
| RB Pierre Strong Jr. - Hamstring, Limited Practice on Wednesday. Questionable for Week 6 at Philadelphia |
WR Britain Covey - Shoulder, IR. Injured Reserve. Expected Return - Week 9 |
| DT Maurice Hurst - Ankle, IR. Injured Reserve. Expected Return - Week 6 |
OT Le'Raven Clark - Undisclosed, IR. Injured Reserve |
| SAF Grant Delpit - Concussion, Did Not Practice on Wednesday. Questionable for Week 6 at Philadelphia |
CB James Bradberry - Lower Leg, IR. Injured Reserve. Expected Return - Week 6 |
| LS Charley Hughlett - Ribs, IR. Injured Reserve. Expected Return - Week 11 |
TE Albert Okwuegbunam - Abdomen, IR. Injured Reserve. Expected Return - Week 6 |
| RB D'Onta Foreman - Ankle, Did Not Practice on Wednesday. Questionable for Week 6 at Philadelphia |
SAF Sydney Brown - Knee - ACL, Physically Unable to Perform. Expected Return - Week 6 |
| DE Myles Garrett - Achilles, Did Not Practice on Wednesday. Questionable for Week 6 at Philadelphia |
WR Ainias Smith - Ankle, IR. Injured Reserve. Expected Return - Week 6 |
| SAF Ronnie Hickman - Ankle, Did Not Practice on Wednesday. Questionable for Week 6 at Philadelphia |
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| OT James Hudson - Shoulder, Questionable for Week 6 at Philadelphia |
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| MLB Jordan Hicks - Elbow, Limited Practice on Wednesday. Questionable for Week 6 at Philadelphia |
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| OT Jack Conklin - Hamstring, Limited Practice on Wednesday. Questionable for Week 6 at Philadelphia |
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| TE David Njoku - Knee, Did Not Practice on Wednesday. Questionable for Week 6 at Philadelphia |
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| C Ethan Pocic - Knee, Did Not Practice on Wednesday. Questionable for Week 6 at Philadelphia |
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| CB Denzel Ward - Hamstring, Did Not Practice on Wednesday. Questionable for Week 6 at Philadelphia |
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| DE Alex Wright - Triceps, IR. Injured Reserve |
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| RB Nyheim Hines - Knee - ACL, NFI-R for Week 6 at Philadelphia |
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| RB Nick Chubb - Knee - ACL + MCL, Physically Unable to Perform. Expected Return - Week 6 |
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| OG Wyatt Teller - Knee - MCL, IR. Injured Reserve. Expected Return - Week 8 |
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| LB Brandon Bouyer-Randle - Undisclosed, IR. Injured Reserve |
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| WR David Bell - Hip, IR. Injured Reserve |
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| LB Tony Fields II - Ankle, IR. Injured Reserve. Expected Return - Week 6 |
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| DB Myles Harden - Shin, IR. Injured Reserve. Expected Return - Week 6 |
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| DB Juan Thornhill - Calf, IR. Injured Reserve. Expected Return - Week 6 |
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